Publications

Long-term Local Control Following CEA-targeted Fluorescence-guided Surgery in Patients With Locally Advanced and Recurrent Rectal Cancer

Warmerdam MI, Creemers DMJ, Kusters M, Peeters KCMJ, Holman FA, Mieog JSD, Cailler F, Burger PJWA, Burggraaf J, Rutten HJT, Verhoef C, Vahrmeijer AL, Hilling DE. Long-term Local Control Following CEA-targeted Fluorescence-guided Surgery in Patients With Locally Advanced and Recurrent Rectal Cancer. Mol Imaging Biol. 2025 Jun 5. doi: 10.1007/s11307-025-02021-4

Impact of Neoadjuvant Treatment on Target Expression in Rectal Cancer for Near-Infrared Tumor Imaging

Zonoobi E, Neijenhuis LKA, Lemij AA, Linders DGJ, Nazemalhosseini-Mojarad E, Bhairosingh SS, Dekker-Ensink NG, van Vlierberghe RLP, Peeters KCMJ, Holman FA, Tollenaar RAEM, Hilling DE, Crobach ASLP, Vahrmeijer AL, Kuppen PJK. Impact of Neoadjuvant Treatment on Target Expression in Rectal Cancer for Near-Infrared Tumor Imaging. Cancers (Basel). 2025 Jun 12;17(12):1958.

Feasibility of Anti-CEA Dye Conjugate for Cancer-Specific Imaging in Gastric Cancer Cell Lines and Mouse Xenograft Models

Jeong K, Koo A.E, Yoo J, Shin J-Y, Lim L, Kim H-M, Park J-Y, Lee Y-S, Kwak Y-J, Lee H-S,Yoo Y-R, Framery B, Dumas K, Cailler F, Pèlegrin A, Park D-J,Yang H-K, Kong S-H, Lee H-J.Feasibility of Anti-CEA Dye Conjugate for Cancer-Specific Imaging in Gastric Cancer Cell Lines and Mouse Xenograft Models. Cancers. 2025 Sept 2025;17:2937.

Semi-automatic standardized analysis method to objectively evaluate near-infrared fluorescent dyes in image-guided surgery

Dijkhuis TH, Bijlstra OD, Warmerdam MI, Faber RA, Linders DGJ, Galema HA, Broersen A, Dijkstra J, Kuppen PJK, Vahrmeijer AL, Mieog JSD. Semi-automatic standardized analysis method to objectively evaluate near-infrared fluorescent dyes in image-guided surgery. J Biomed Opt. 2024 Feb;29(2):026001.

Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study

Meijer RPJ, Galema HA, Faber RA, Bijlstra OD, Maat APWM, Cailler F, Braun J, Keereweer S, Hilling DE, Burggraaf J, Vahrmeijer AL, Hutteman M; SGM-CLM study group. Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study. Eur J Nucl Med Mol Imaging. 2023 Aug 8.

Carcinoembryonic Antigen-Related Cell Adhesion Molecule Type 5 Receptor-Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer: A Nonrandomized Controlled Trial

Azari F, Meijer RPJ, Kennedy GT, Hanna A, Chang A, Nadeem B, Din A, Pèlegrin A, Framery B, Cailler F, Sullivan NT, Kucharczuk J, Martin LW, Vahrmeijer AL, Singhal S. Carcinoembryonic Antigen-Related Cell Adhesion Molecule Type 5 Receptor-Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer: A Nonrandomized Controlled Trial. JAMA Netw Open. 2023 Jan 3;6(1):e2252885.

Fluorescence-guided surgery in colorectal cancer; A review on clinical results and future perspectives

Galema HA, Meijer RPJ, Lauwerends LJ, Verhoef C, Burggraaf J, Vahrmeijer AL, Hutteman M, Keereweer S, Hilling DE. Fluorescence-guided surgery in colorectal cancer; A review on clinical results and future perspectives. Eur J Surg Oncol. 2022 Apr;48(4):810-821.

Glycoprotein Receptor CEACAM5-Targeted Intraoperative Molecular Imaging Tracer in NSCLC

Azari F, Kennedy GT, Chang A, Bernstein E, Nadeem B, Pèlegrin A, Cailler F, Sullivan NT, Kucharczuk J, Singhal S. Glycoprotein Receptor CEACAM5-Targeted Intraoperative Molecular Imaging Tracer in NSCLC. Ann Thorac Surg. 2022 May 26:S0003-4975(22)00731-7. 

Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings

Azari F, Kennedy G, Bernstein E, Hadjipanayis C, Vahrmeijer A, Smith B, Rosenthal E, Sumer B, Tian J, Henderson E, Lee A, Nguyen Q, Gibbs S, Pogue B, Orringer D, Charalampaki C, Martin L, Tanyi J, Lee M, Lee JY, Singhal S. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901.

Intraoperative detection of colorectal and pancreatic liver metastases using SGM-101, a fluorescent antibody targeting CEA

Meijer RPJ, de Valk KS, Deken MM, Boogerd LSF, Hoogstins CES, Bhairosingh SS, Swijnenburg RJ, Bonsing BA, Framery B, Fariña Sarasqueta A, Putter H, Hilling DE, Burggraaf J, Cailler F, Mieog JSD, Vahrmeijer AL. Intraoperative detection of colorectal and pancreatic liver metastases using SGM-101, a fluorescent antibody targeting CEA. Eur J Surg Oncol. 2021 Mar;47(3 Pt B):667-673.

• PMCID: PMC33158638
• DOI: 10.1016/j.ejso.2020.10.034

Multimodal CEA-Targeted Image-Guided Colorectal Cancer Surgery using 111In-Labeled SGM-101

de Gooyer JM, Elekonawo FMK, Bos DL, van der Post RS, Pèlegrin A, Framery B, Cailler F, Vahrmeijer AL, de Wilt JHW, Rijpkema M. Multimodal CEA-Targeted Image-Guided Colorectal Cancer Surgery using 111In-Labeled SGM-101. Clin Cancer Res. 2020 Nov 15;26(22):5934-5942

• PMCID: PMC32900795
• DOI:10.1158/1078-0432.CCR-20-2255

Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer

de Valk KS, Deken MM, Schaap DP, Meijer RP, Boogerd LS, Hoogstins CE, van der Valk MJ, Kamerling IM, Bhairosingh SS, Framery B, Hilling DE, Peeters KC, Holman FA, Kusters M, Rutten HJ, Cailler F, Burggraaf J, Vahrmeijer AL. (2020) Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer. Ann Surg Oncol. 28(3):1832-1844.

Carcinoembryonic antigen‐specific, fluorescent image‐guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer

Schaap D.P., de Valk K. S., Deken M. M., Meijer R. P. J., Burggraaf, J., Vahrmeijer A. L., and Kusters M., on behalf of the SGM‐101 study group. (2020). Carcinoembryonic antigen‐specific, fluorescent image‐guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer. Br J Surg. 107(4): 334–337.

Antibodies, tools of choice for fluorescence-guided surgery

Pèlegrin A., Gutowski M. and Cailler F. (2019) Antibodies, tools of choice for fluorescence-guided surgery. Med Sci (Paris) 35(12):1066-1071.

Toxicity and pharmacokinetic profile of SGM-101, a fluorescent anti-CEA chimeric antibody for fluorescence imaging of tumors in patients

Framery B., Gutowski M., Dumas K., Evrard A., Muller N., Dubois V., Quinonero J., Scherninski F., Pèlegrin A. and Cailler F. (2019). Toxicity and pharmacokinetic profile of SGM-101, a fluorescent anti-CEA chimeric antibody for fluorescence imaging of tumors in patients. Toxicol Rep. 6:409-415.

Fluorescent-guided surgery for sentinel lymph node detection in gastric cancer and carcinoembryonic antigen targeted fluorescent-guided surgery in colorectal and pancreatic cancer

Vuijk FA, Hilling DE, Mieog JSD, Vahrmeijer AL. Fluorescent-guided surgery for sentinel lymph node detection in gastric cancer and carcinoembryonic antigen targeted fluorescent-guided surgery in colorectal and pancreatic cancer. J Surg Oncol. 2018 Aug;118(2):315-323.

Image-Guided Surgery in Patients With Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent

Hoogstins C.E.S., Boogerd L.S.F., Mulder B.G.S., Mieog J.S.D., Swijnenburg R.J., van de Velde C.J.H., Farina-Sarasqueta A., Bonsing B.A., Framery B., Pèlegrin A., Gutowski M., Cailler F., Burggraaf J. and Vahrmeijer A.L. (2018). Image-Guided Surgery in Patients With Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent. Ann Surg Oncol 25(11):3350-3357.

Safety and Effectiveness of SGM-101, a Fluorescent Antibody Targeting Carcinoembryonic Antigen, for Intraoperative Detection of Colorectal Cancer: A Dose-Escalation Pilot Study

Boogerd L.S.F., Hoogstins C.E.S., Schaap D.P., Kusters M., Handgraaf J.J.M., van der Valk M.J.M., Holman F.A., Peeters K.C.M.J., Mieog J.S.D., van de Velde C.J.H., Farina-Sarasqueta A., van Lijnschoten I., Framery B., Pèlegrin A., Gutowski M., Nienhuijs S.W., de Hingh I.H.J.T., Nieuwenhuijzen G.A.P., Rutten A.J.T., Cailler F., Burggraaf J. and Vahrmeijer A.L. (2018). Safety and Effectiveness of SGM-101, a Fluorescent Antibody Targeting Carcinoembryonic Antigen, for Intraoperative Detection of Colorectal Cancer: A Dose-Escalation Pilot Study. Lancet Gastroenterol Hepatol. 3(3):181-191.

• PMCID: PMC29361435
• DOI:10.1016/S2468-1253(17)30395-3

SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery

Gutowski, M. Framery, B., Boonstra M.C., Garambois, V., Quenet F., Dumas K., Scherninski F., Cailler F., Vahrmeijer A.L. and Pèlegrin A. (2017). SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery. Surgical Oncology 26: 153-162.

Intraoperative immunophotodetection for radical resection of cancers: evaluation in an experimental model

Gutowski, M, Carcenac, M, Pourquier, D, Larroque, C, Saint-Aubert, B, Rouanet, P, and Pèlegrin, A. (2001). Intraoperative immunophotodetection for radical resection of cancers: evaluation in an experimental model. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 7, 1142–1148.

• PMCID: PMC11350877
• DOI: